Chaz Langelier, MD, PhD

Associate Medical Director
Medicine

My research addresses the critical need for better infectious disease diagnostics by leveraging metagenomic next generation sequencing (mNGS) to simultaneously evaluate host gene expression, airway microbes and antibiotic resistance genes from a single clinical sample. In addition, my work aims to understand the biology of infectious lung disease by elucidating host, pathogen and environmental factors that influence respiratory infection susceptibility, severity and contribution to lung injury.

Publications: 

A high five for TB screening

Science Translational Medicine

Langelier, C.

Integrating host response and unbiased microbe detection for lower respiratory tract infection diagnosis in critically ill adults.

Proceedings of the National Academy of Sciences of the United States of America

Langelier C, Kalantar KL, Moazed F, Wilson MR, Crawford ED, Deiss T, Belzer A, Bolourchi S, Caldera S, Fung M, Jauregui A, Malcolm K, Lyden A, Khan L, Vessel K, Quan J, Zinter M, Chiu CY, Chow ED, Wilson J, Miller S, Matthay MA, Pollard KS, Christenson S, Calfee CS, DeRisi JL

Pulmonary Metagenomic Sequencing Suggests Missed Infections in Immunocompromised Children.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Zinter MS, Dvorak CC, Mayday MY, Iwanaga K, Ly NP, McGarry ME, Church GD, Faricy LE, Rowan CM, Hume JR, Steiner ME, Crawford ED, Langelier C, Kalantar K, Chow ED, Miller S, Shimano K, Melton A, Yanik GA, Sapru A, DeRisi JL

The resistance potential of a quintessential commensal

Science Translational Medicine

Langelier, Chaz

A Metagenomic Comparison of Tracheal Aspirate and Mini-Bronchial Alveolar Lavage for Assessment of Respiratory Microbiota

BioRxiv (preprint)

Katrina Kalantar, Farzad Moazed, Stephanie Christenson, Jenny Wilson, Thomas Deiss, Annika Belzer, Kathryn Vessell, Alejandra Jauregui, Samaneh Boulourchi, Joseph L DeRisi, Carolyn Calfee, Charles Langelier

A molecular warning system for invasive pneumococcus

Science Translational Medicine

Chaz Langelier

Malaria and the microbiome: a systematic review.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Ippolito MM, Denny JE, Langelier C, Sears CL, Schmidt NW

A firsthand view of how secondhand smoke disrupts airway immunity

Science Translational Medicine

Chaz Langelier

Chronic Meningitis Investigated via Metagenomic Next-Generation Sequencing.

JAMA neurology

Wilson MR, O'Donovan BD, Gelfand JM, Sample HA, Chow FC, Betjemann JP, Shah MP, Richie MB, Gorman MP, Hajj-Ali RA, Calabrese LH, Zorn KC, Chow ED, Greenlee JE, Blum JH, Green G, Khan LM, Banerji D, Langelier C, Bryson-Cahn C, Harrington W, Lingappa JR, Shanbhag NM, Green AJ, Brew BJ, Soldatos A, Strnad L, Doernberg SB, Jay CA, Douglas V, Josephson SA, DeRisi JL

Breakthrough Invasive Fungal Infections on Isavuconazole Prophylaxis and Treatment: What is Happening in the Real-world Setting?

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Fung M, Schwartz BS, Doernberg SB, Langelier C, Lo M, Graff L, Tan M, Logan AC, Chin-Hong P, Babik JM

Metagenomic Sequencing Detects Respiratory Pathogens in Hematopoietic Cellular Transplant Patients.

American journal of respiratory and critical care medicine

Langelier C, Zinter MS, Kalantar K, Yanik GA, Christenson S, O'Donovan B, White C, Wilson M, Sapru A, Dvorak CC, Miller S, Chiu CY, DeRisi JL

IFN-stimulated Gene Expression, Type 2 Inflammation, and Endoplasmic Reticulum Stress in Asthma.

American journal of respiratory and critical care medicine

Bhakta NR, Christenson SA, Nerella S, Solberg OD, Nguyen CP, Choy DF, Jung KL, Garudadri S, Bonser LR, Pollack JL, Zlock LT, Erle DJ, Langelier C, Derisi JL, Arron JR, Fahy JV, Woodruff PG

Transcriptomic profiling reveals gene expression kinetics in patients with hypoxia and high altitude pulmonary edema.

Gene

Yuhong L, Tana W, Zhengzhong B, Feng T, Qin G, Yingzhong Y, Wei G, Yaping W, Langelier C, Rondina MT, Ge RL

Lung Microbiota is Related to Smoking Status and to Development of ARDS in Critically Ill Trauma Patients.

American journal of respiratory and critical care medicine

Panzer AR, Lynch SV, Langelier C, Christie JD, McCauley K, Nelson M, Cheung CK, Benowitz NL, Cohen MJ, Calfee CS

Use of isavuconazole in a patient with voriconazole-induced QTc prolongation.

Transplant infectious disease : an official journal of the Transplantation Society

Trang TP, Hanretty AM, Langelier C, Yang K

Assessing biosynthetic potential of agricultural groundwater through metagenomic sequencing: A diverse anammox community dominates nitrate-rich groundwater.

PloS one

Ludington WB, Seher TD, Applegate O, Li X, Kliegman JI, Langelier C, Atwill ER, Harter T, DeRisi JL

Antimicrobial Resistance: A Call to Action!

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Brown L, Langelier C, Reid MJ, Rutishauser RL, Strnad L

Raccoon Roundworm Infection Associated with Central Nervous System Disease and Ocular Disease - Six States, 2013-2015.

MMWR. Morbidity and mortality weekly report

Sircar AD, Abanyie F, Blumberg D, Chin-Hong P, Coulter KS, Cunningham D, Huskins WC, Langelier C, Reid M, Scott BJ, Shirley DA, Babik JM, Belova A, Sapp SG, McAuliffe I, Rivera HN, Yabsley MJ, Montgomery SP

Baylisascaris procyonis-Associated Meningoencephalitis in a Previously Healthy Adult, California, USA.

Emerging infectious diseases

Langelier C, Reid MJ, Halabi C, Witek N, LaRiviere A, Shah M, Wilson MR, Chin-Hong P, Douglas V, Kazacos KR, Babik JM

Monocyte polarization in children with falciparum malaria: relationship to nitric oxide insufficiency and disease severity.

Scientific reports

Weinberg JB, Volkheimer AD, Rubach MP, Florence SM, Mukemba JP, Kalingonji AR, Langelier C, Chen Y, Bush M, Yeo TW, Granger DL, Anstey NM, Mwaikambo ED

An Expression of Clinical Significance: Exploring the Human Genome to Understand the Variable Response to Rhinovirus.

American journal of respiratory and critical care medicine

Langelier C, Christenson SA

Two Rapidly Growing Mycobacterial Species Isolated from a Brain Abscess: First Whole-Genome Sequences of Mycobacterium immunogenum and Mycobacterium llatzerense.

Journal of clinical microbiology

Greninger AL, Langelier C, Cunningham G, Keh C, Melgar M, Chiu CY, Miller S

Clinical, genomic, and metagenomic characterization of oral tongue squamous cell carcinoma in patients who do not smoke.

Head & neck

Li R, Faden DL, Fakhry C, Langelier C, Jiao Y, Wang Y, Wilkerson MD, Pedamallu CS, Old M, Lang J, Loyo M, Ahn SM, Tan M, Gooi Z, Chan J, Richmon J, Wood LD, Hruban RH, Bishop J, Westra WH, Chung CH, Califano J, Gourin CG, Bettegowda C, Meyerson M, Papadopoulos N, Kinzler KW, Vogelstein B, DeRisi JL, Koch WM, Agrawal N

Think global, act local: chronic dysuria and sterile pyuria in an Eritrean-American woman.

BMJ case reports

Rutishauser RL, Langelier C, Baxi SM, Hanks D, Chin-Hong P

Discovery of novel small-molecule HIV-1 replication inhibitors that stabilize capsid complexes.

Antimicrobial agents and chemotherapy

Lamorte L, Titolo S, Lemke CT, Goudreau N, Mercier JF, Wardrop E, Shah VB, von Schwedler UK, Langelier C, Banik SS, Aiken C, Sundquist WI, Mason SW

Structural basis for ESCRT-III protein autoinhibition.

Nature structural & molecular biology

Bajorek M, Schubert HL, McCullough J, Langelier C, Eckert DM, Stubblefield WM, Uter NT, Myszka DG, Hill CP, Sundquist WI

Biochemical characterization of a recombinant TRIM5alpha protein that restricts human immunodeficiency virus type 1 replication.

Journal of virology

Langelier CR, Sandrin V, Eckert DM, Christensen DE, Chandrasekaran V, Alam SL, Aiken C, Olsen JC, Kar AK, Sodroski JG, Sundquist WI

The molecular mechanism of hepcidin-mediated ferroportin down-regulation.

Molecular biology of the cell

De Domenico I, Ward DM, Langelier C, Vaughn MB, Nemeth E, Sundquist WI, Ganz T, Musci G, Kaplan J

Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain.

Nature structural & molecular biology

Alam SL, Langelier C, Whitby FG, Koirala S, Robinson H, Hill CP, Sundquist WI

Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release.

Journal of virology

Langelier C, von Schwedler UK, Fisher RD, De Domenico I, White PL, Hill CP, Kaplan J, Ward D, Sundquist WI

Inflammatory cytokines and cell death in BEAS-2B lung cells treated with soil dust, lipopolysaccharide, and surface-modified particles.

Toxicological sciences : an official journal of the Society of Toxicology

Veranth JM, Reilly CA, Veranth MM, Moss TA, Langelier CR, Lanza DL, Yost GS

Recognition of the nonpolar base 4-methylindole in DNA by the DNA repair adenine glycosylase MutY.

Organic letters

Chepanoske CL, Langelier CR, Chmiel NH, David SS

Custom Person Group: