Chaz Langelier, MD, PhD

Associate Medical Director
Medicine

My research addresses the critical need for better infectious disease diagnostics by leveraging metagenomic next generation sequencing (mNGS) to simultaneously evaluate host gene expression, airway microbes and antibiotic resistance genes from a single clinical sample. In addition, my work aims to understand the biology of infectious lung disease by elucidating host, pathogen and environmental factors that influence respiratory infection susceptibility, severity and contribution to lung injury.

Publications: 

Clinical features, diagnostics, and outcomes of patients presenting with acute respiratory illness: A retrospective cohort study of patients with and without COVID-19.

EClinicalMedicine

Shah SJ, Barish PN, Prasad PA, Kistler A, Neff N, Kamm J, Li LM, Chiu CY, Babik JM, Fang MC, Kangelaris KN, Langelier C, Abe-Jones Y, Alipanah N, Alvarez FN, Botvinnik OB, Castaneda G

Investigating Transfusion-Related Sepsis using Culture-Independent Metagenomic Sequencing.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Crawford E, Kamm J, Miller S, Li LM, Caldera S, Lyden A, Yokoe D, Nichols A, Tran NK, Barnard SE, Conner PM, Nambiar A, Zinter MS, Moayeri M, Serpa PH, Prince BC, Quan J, Sit R, Tan M, Phelps M, DeRisi JL, Tato CM, Langelier C

Dose-Dependent Pulmonary Toxicity of Aerosolized Vitamin E Acetate.

American journal of respiratory cell and molecular biology

Matsumoto S, Fang X, Traber MG, Jones KD, Langelier C, Hayakawa Serpa P, Calfee CS, Matthay MA, Gotts JE

Sepsis from an apheresis platelet contaminated with Acinetobacter calcoaceticus/baumannii complex bacteria and Staphylococcus saprophyticus after pathogen reduction.

Transfusion

Fridey JL, Stramer SL, Nambiar A, Moayeri M, Bakkour S, Langelier C, Crawford E, Lu T, Lanteri MC, Kamm J, Miller S, Wagner SJ, Benjamin RJ, Busch MP

Draft Genome Sequence of an Extensively Drug-Resistant Salmonella enterica Serovar Typhi Strain from a Returned Traveler from Pakistan.

Microbiology resource announcements

Hao S, Veuthey T, Caldera S, Serpa PH, Haller B, Tan M, Neff N, Madera S, Langelier C

Genomic Profiling of Evolving Daptomycin Resistance in a Patient with Recurrent Staphylococcus argenteus Sepsis.

Antimicrobial agents and chemotherapy

Hao S, Abdelghany M, Lyden A, Sit R, Tan M, Tato CM, DeRisi JL, Miller S, Doernberg SB, Langelier C

Clinical Outcomes and Serologic Response in Solid Organ Transplant Recipients with COVID-19: A Case Series from the United States.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Fung M, Chiu CY, DeVoe C, Doernberg SB, Schwartz BS, Langelier C, Henrich TJ, Yokoe D, Davis J, Hays SR, Chandran S, Kukreja J, Ng D, Prostko J, Taylor R, Reyes K, Bainbridge E, Bond A, Chin-Hong P, Babik JM

The gut microbiome's role in the development, maintenance, and outcomes of sepsis.

Critical care (London, England)

Adelman MW, Woodworth MH, Langelier C, Busch LM, Kempker JA, Kraft CS, Martin GS

Upper airway gene expression differentiates COVID-19 from other acute respiratory illnesses and reveals suppression of innate immune responses by SARS-CoV-2.

medRxiv : the preprint server for health sciences

Mick E, Kamm J, Pisco AO, Ratnasiri K, Babik JM, Calfee CS, Castaneda G, DeRisi JL, Detweiler AM, Hao S, Kangelaris KN, Kumar GR, Li LM, Mann SA, Neff N, Prasad PA, Serpa PH, Shah SJ, Spottiswoode N, Tan M, Christenson SA, Kistler A, Langelier C

Clinical features, diagnostics, and outcomes of patients presenting with acute respiratory illness: a comparison of patients with and without COVID-19.

medRxiv : the preprint server for health sciences

Shah SJ, Barish PN, Prasad PA, Kistler AL, Neff N, Kamm J, Li LM, Chiu CY, Babick JM, Fang MC, Abe-Jones Y, Alipanah N, Alvarez FN, Botvinnik OB, Davis JM, Castenada GD, Consortium C, Dadasovich RM, Deng X, DeRisi JL, Detweiler AM, Federman S, Haliburton JR, Hao SL, Kerkhoff AD, Kumar R, Malcolm K, Mann SA, Martinez SP, Marya R, Mick E, Mwakibete LL, Najafi N, Peluso MJ, Phelps MS, Pisco AO, Ratnasiri K, Rubio LA, Sellas AB, Sherwood KD, Sheu J, Spottiswoode N, Tan M, Yu G, Kangelaris KN, Langelier C

Central Nervous System Virus Infection in African Children with Cerebral Malaria.

The American journal of tropical medicine and hygiene

Postels DG, Osei-Tutu L, Seydel KB, Xu Q, Li C, Taylor TE, John CC, Mallewa M, Solomon T, Agbenyega T, Ansong D, Opoka RO, Khan LM, Leon KE, DeRisi JL, Langelier C, Wilson MR

Genomic and serologic characterization of enterovirus A71 brainstem encephalitis.

Neurology(R) neuroimmunology & neuroinflammation

Leon KE, Schubert RD, Casas-Alba D, Hawes IA, Ramachandran PS, Ramesh A, Pak JE, Wu W, Cheung CK, Crawford ED, Khan LM, Launes C, Sample HA, Zorn KC, Cabrerizo M, Valero-Rello A, Langelier C, Muñoz-Almagro C, DeRisi JL, Wilson MR

Detection of Pneumonia Pathogens from Plasma Cell-Free DNA.

American journal of respiratory and critical care medicine

Langelier C, Fung M, Caldera S, Deiss T, Lyden A, Prince BC, Hayakawa Serpa P, Moazed F, Chin-Hong P, DeRisi JL, Calfee CS

Unbiased Metagenomic Sequencing for Pediatric Meningitis in Bangladesh Reveals Neuroinvasive Chikungunya Virus Outbreak and Other Unrealized Pathogens.

mBio

Saha S, Ramesh A, Kalantar K, Malaker R, Hasanuzzaman M, Khan LM, Mayday MY, Sajib MSI, Li LM, Langelier C, Rahman H, Crawford ED, Tato CM, Islam M, Juan YF, de Bourcy C, Dimitrov B, Wang J, Tang J, Sheu J, Egger R, De Carvalho TR, Wilson MR, Saha SK, DeRisi JL

FLASH: a next-generation CRISPR diagnostic for multiplexed detection of antimicrobial resistance sequences.

Nucleic acids research

Quan J, Langelier C, Kuchta A, Batson J, Teyssier N, Lyden A, Caldera S, McGeever A, Dimitrov B, King R, Wilheim J, Murphy M, Ares LP, Travisano KA, Sit R, Amato R, Mumbengegwi DR, Smith JL, Bennett A, Gosling R, Mourani PM, Calfee CS, Neff NF, Chow ED, Kim PS, Greenhouse B, DeRisi JL, Crawford ED

Microbiome and Antimicrobial Resistance Gene Dynamics in International Travelers.

Emerging infectious diseases

Langelier C, Graves M, Kalantar K, Caldera S, Durrant R, Fisher M, Backman R, Tanner W, DeRisi JL, Leung DT

Metagenomic next-generation sequencing of samples from pediatric febrile illness in Tororo, Uganda.

PloS one

Ramesh A, Nakielny S, Hsu J, Kyohere M, Byaruhanga O, de Bourcy C, Egger R, Dimitrov B, Juan YF, Sheu J, Wang J, Kalantar K, Langelier C, Ruel T, Mpimbaza A, Wilson MR, Rosenthal PJ, DeRisi JL

Sepsis Attributed to Bacterial Contamination of Platelets Associated with a Potential Common Source - Multiple States, 2018.

MMWR. Morbidity and mortality weekly report

Jones SA, Jones JM, Leung V, Nakashima AK, Oakeson KF, Smith AR, Hunter R, Kim JJ, Cumming M, McHale E, Young PP, Fridey JL, Kelley WE, Stramer SL, Wagner SJ, West FB, Herron R, Snyder E, Hendrickson JE, Peaper DR, Gundlapalli AV, Langelier C, Miller S, Nambiar A, Moayeri M, Kamm J, Moulton-Meissner H, Annambhotla P, Gable P, McAllister GA, Breaker E, Sula E, Halpin AL, Basavaraju SV

Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis.

The New England journal of medicine

Wilson MR, Sample HA, Zorn KC, Arevalo S, Yu G, Neuhaus J, Federman S, Stryke D, Briggs B, Langelier C, Berger A, Douglas V, Josephson SA, Chow FC, Fulton BD, DeRisi JL, Gelfand JM, Naccache SN, Bender J, Dien Bard J, Murkey J, Carlson M, Vespa PM, Vijayan T, Allyn PR, Campeau S, Humphries RM, Klausner JD, Ganzon CD, Memar F, Ocampo NA, Zimmermann LL, Cohen SH, Polage CR, DeBiasi RL, Haller B, Dallas R, Maron G, Hayden R, Messacar K, Dominguez SR, Miller S, Chiu CY

Sentinel Case of Candida auris in the Western United States Following Prolonged Occult Colonization in a Returned Traveler from India.

Microbial drug resistance (Larchmont, N.Y.)

Woodworth MH, Dynerman D, Crawford ED, Doernberg SB, Ramirez-Avila L, Serpa PH, Nichols A, Li LM, Lyden A, Tato CM, Miller S, Derisi JL, Langelier C

Detection of Cryptococcus DNA by metagenomic next-generation sequencing in symptomatic cryptococcal antigenemia.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Ramachandran PS, Cresswell FV, Meya DB, Crawford ED, DeRisi JL, Boulware DR, Wilson MR

Pulmonary Metagenomic Sequencing Suggests Missed Infections in Immunocompromised Children.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Zinter MS, Dvorak CC, Mayday MY, Iwanaga K, Ly NP, McGarry ME, Church GD, Faricy LE, Rowan CM, Hume JR, Steiner ME, Crawford ED, Langelier C, Kalantar K, Chow ED, Miller S, Shimano K, Melton A, Yanik GA, Sapru A, DeRisi JL

Bergeyella cardium: Clinical Characteristics and Draft Genome of an Emerging Pathogen in Native and Prosthetic Valve Endocarditis.

Open forum infectious diseases

Mulliken JS, Langelier C, Budak JZ, Miller S, Dynerman D, Hao S, Li LM, Crawford E, Lyden A, Woodworth MH, DeRisi JL, Desmond E, Browne C, Luu A, Grandis DJ, Grossman W, Deuse T, Melcher GP

A Metagenomic Comparison of Tracheal Aspirate and Mini-Bronchial Alveolar Lavage for Assessment of Respiratory Microbiota.

American journal of physiology. Lung cellular and molecular physiology

Kalantar KL, Moazed F, Christenson SC, Wilson J, Deiss T, Belzer A, Vessel K, Caldera S, Jauregui A, Bolourchi S, DeRisi JL, Calfee CS, Langelier C

A high five for TB screening

Science Translational Medicine

Langelier, C.

Malaria and the microbiome: a systematic review.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Ippolito MM, Denny JE, Langelier C, Sears CL, Schmidt NW

Integrating host response and unbiased microbe detection for lower respiratory tract infection diagnosis in critically ill adults.

Proceedings of the National Academy of Sciences of the United States of America

Langelier C, Kalantar KL, Moazed F, Wilson MR, Crawford ED, Deiss T, Belzer A, Bolourchi S, Caldera S, Fung M, Jauregui A, Malcolm K, Lyden A, Khan L, Vessel K, Quan J, Zinter M, Chiu CY, Chow ED, Wilson J, Miller S, Matthay MA, Pollard KS, Christenson S, Calfee CS, DeRisi JL

Breakthrough Invasive Fungal Infections on Isavuconazole Prophylaxis and Treatment: What is Happening in the Real-world Setting?

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Fung M, Schwartz BS, Doernberg SB, Langelier C, Lo M, Graff L, Tan M, Logan AC, Chin-Hong P, Babik JM

The resistance potential of a quintessential commensal

Science Translational Medicine

Langelier, Chaz

Chronic Meningitis Investigated via Metagenomic Next-Generation Sequencing.

JAMA neurology

Wilson MR, O'Donovan BD, Gelfand JM, Sample HA, Chow FC, Betjemann JP, Shah MP, Richie MB, Gorman MP, Hajj-Ali RA, Calabrese LH, Zorn KC, Chow ED, Greenlee JE, Blum JH, Green G, Khan LM, Banerji D, Langelier C, Bryson-Cahn C, Harrington W, Lingappa JR, Shanbhag NM, Green AJ, Brew BJ, Soldatos A, Strnad L, Doernberg SB, Jay CA, Douglas V, Josephson SA, DeRisi JL

A molecular warning system for invasive pneumococcus

Science Translational Medicine

Chaz Langelier

A firsthand view of how secondhand smoke disrupts airway immunity

Science Translational Medicine

Chaz Langelier

Lung Microbiota is Related to Smoking Status and to Development of ARDS in Critically Ill Trauma Patients.

American journal of respiratory and critical care medicine

Panzer AR, Lynch SV, Langelier C, Christie JD, McCauley K, Nelson M, Cheung CK, Benowitz NL, Cohen MJ, Calfee CS

Metagenomic Sequencing Detects Respiratory Pathogens in Hematopoietic Cellular Transplant Patients.

American journal of respiratory and critical care medicine

Langelier C, Zinter MS, Kalantar K, Yanik GA, Christenson S, O'Donovan B, White C, Wilson M, Sapru A, Dvorak CC, Miller S, Chiu CY, DeRisi JL

IFN-stimulated Gene Expression, Type 2 Inflammation, and Endoplasmic Reticulum Stress in Asthma.

American journal of respiratory and critical care medicine

Bhakta NR, Christenson SA, Nerella S, Solberg OD, Nguyen CP, Choy DF, Jung KL, Garudadri S, Bonser LR, Pollack JL, Zlock LT, Erle DJ, Langelier C, Derisi JL, Arron JR, Fahy JV, Woodruff PG

Transcriptomic profiling reveals gene expression kinetics in patients with hypoxia and high altitude pulmonary edema.

Gene

Yuhong L, Tana W, Zhengzhong B, Feng T, Qin G, Yingzhong Y, Wei G, Yaping W, Langelier C, Rondina MT, Ge RL

Use of isavuconazole in a patient with voriconazole-induced QTc prolongation.

Transplant infectious disease : an official journal of the Transplantation Society

Trang TP, Hanretty AM, Langelier C, Yang K

Assessing biosynthetic potential of agricultural groundwater through metagenomic sequencing: A diverse anammox community dominates nitrate-rich groundwater.

PloS one

Ludington WB, Seher TD, Applegate O, Li X, Kliegman JI, Langelier C, Atwill ER, Harter T, DeRisi JL

Antimicrobial Resistance: A Call to Action!

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Brown L, Langelier C, Reid MJ, Rutishauser RL, Strnad L

Raccoon Roundworm Infection Associated with Central Nervous System Disease and Ocular Disease - Six States, 2013-2015.

MMWR. Morbidity and mortality weekly report

Sircar AD, Abanyie F, Blumberg D, Chin-Hong P, Coulter KS, Cunningham D, Huskins WC, Langelier C, Reid M, Scott BJ, Shirley DA, Babik JM, Belova A, Sapp SG, McAuliffe I, Rivera HN, Yabsley MJ, Montgomery SP

Baylisascaris procyonis-Associated Meningoencephalitis in a Previously Healthy Adult, California, USA.

Emerging infectious diseases

Langelier C, Reid MJ, Halabi C, Witek N, LaRiviere A, Shah M, Wilson MR, Chin-Hong P, Douglas V, Kazacos KR, Babik JM

Monocyte polarization in children with falciparum malaria: relationship to nitric oxide insufficiency and disease severity.

Scientific reports

Weinberg JB, Volkheimer AD, Rubach MP, Florence SM, Mukemba JP, Kalingonji AR, Langelier C, Chen Y, Bush M, Yeo TW, Granger DL, Anstey NM, Mwaikambo ED

An Expression of Clinical Significance: Exploring the Human Genome to Understand the Variable Response to Rhinovirus.

American journal of respiratory and critical care medicine

Langelier C, Christenson SA

Two Rapidly Growing Mycobacterial Species Isolated from a Brain Abscess: First Whole-Genome Sequences of Mycobacterium immunogenum and Mycobacterium llatzerense.

Journal of clinical microbiology

Greninger AL, Langelier C, Cunningham G, Keh C, Melgar M, Chiu CY, Miller S

Clinical, genomic, and metagenomic characterization of oral tongue squamous cell carcinoma in patients who do not smoke.

Head & neck

Li R, Faden DL, Fakhry C, Langelier C, Jiao Y, Wang Y, Wilkerson MD, Pedamallu CS, Old M, Lang J, Loyo M, Ahn SM, Tan M, Gooi Z, Chan J, Richmon J, Wood LD, Hruban RH, Bishop J, Westra WH, Chung CH, Califano J, Gourin CG, Bettegowda C, Meyerson M, Papadopoulos N, Kinzler KW, Vogelstein B, DeRisi JL, Koch WM, Agrawal N

Think global, act local: chronic dysuria and sterile pyuria in an Eritrean-American woman.

BMJ case reports

Rutishauser RL, Langelier C, Baxi SM, Hanks D, Chin-Hong P

Discovery of novel small-molecule HIV-1 replication inhibitors that stabilize capsid complexes.

Antimicrobial agents and chemotherapy

Lamorte L, Titolo S, Lemke CT, Goudreau N, Mercier JF, Wardrop E, Shah VB, von Schwedler UK, Langelier C, Banik SS, Aiken C, Sundquist WI, Mason SW

Structural basis for ESCRT-III protein autoinhibition.

Nature structural & molecular biology

Bajorek M, Schubert HL, McCullough J, Langelier C, Eckert DM, Stubblefield WM, Uter NT, Myszka DG, Hill CP, Sundquist WI

Biochemical characterization of a recombinant TRIM5alpha protein that restricts human immunodeficiency virus type 1 replication.

Journal of virology

Langelier CR, Sandrin V, Eckert DM, Christensen DE, Chandrasekaran V, Alam SL, Aiken C, Olsen JC, Kar AK, Sodroski JG, Sundquist WI

The molecular mechanism of hepcidin-mediated ferroportin down-regulation.

Molecular biology of the cell

De Domenico I, Ward DM, Langelier C, Vaughn MB, Nemeth E, Sundquist WI, Ganz T, Musci G, Kaplan J

Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain.

Nature structural & molecular biology

Alam SL, Langelier C, Whitby FG, Koirala S, Robinson H, Hill CP, Sundquist WI

Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release.

Journal of virology

Langelier C, von Schwedler UK, Fisher RD, De Domenico I, White PL, Hill CP, Kaplan J, Ward D, Sundquist WI

Inflammatory cytokines and cell death in BEAS-2B lung cells treated with soil dust, lipopolysaccharide, and surface-modified particles.

Toxicological sciences : an official journal of the Society of Toxicology

Veranth JM, Reilly CA, Veranth MM, Moss TA, Langelier CR, Lanza DL, Yost GS

Recognition of the nonpolar base 4-methylindole in DNA by the DNA repair adenine glycosylase MutY.

Organic letters

Chepanoske CL, Langelier CR, Chmiel NH, David SS

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